Article

Integrated single cell multiomic profiling and functional validation reveal distinct cellular routes to human plasma cell differentiation

2026-02-18

Abstract excerpt

Upon activation, B cells undergo profound transcriptional, epigenetic, and metabolic reprogramming to form antibody secreting plasma cells bearing little resemblance to their progenitors. Here, we used single cell RNA and ATAC sequencing of primary and in vitro differentiating human B cells to identify multiple distinct plasma cell subsets and differentiation routes depending on the starting cell type. In primary...

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Literature Corpus work: 32978e48-d415-5bb7-a5cf-28fac95888b8
DOI: 10.64898/2026.02.16.706247

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