Article

A genome wide CRISPR screen reveals novel determinants of long-lived plasma cell secretory capacity

2025-03-02

Abstract excerpt

Plasma cell subsets vary in their lifespans and ability to sustain humoral immunity. We conducted a genome-wide CRISPR-Cas9 screen in myeloma cells for factors that promote surface expression of CD98, a marker of longevity in mouse plasma cells. A large fraction of genes found to promote CD98 expression in this screen are involved in secretory and other vesicles, including subunits of the V-type ATPase complex. Ge...

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Literature Corpus work: 2884f401-fe6a-5f4c-9958-0f2f7cba683d
DOI: 10.1101/2025.02.28.640639

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