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Differential transcriptome and development of human peripheral plasma cell subsets

2 Apr 2019

Abstract excerpt

Human antibody-secreting cells (ASCs) triggered by immunization are globally recognized as CD19loCD38hiCD27hi. Yet, different vaccines give rise to antibody responses of different longevity, suggesting ASC populations are heterogeneous. We define circulating-ASC heterogeneity in vaccine responses using multicolor flow cytometry, morphology, VH repertoire, and RNA transcriptome analysis. We also tested...

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PMID: 31045577
DOI: 10.1172/jci.insight.126732

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