Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Subclonal immune evasion in non-small cell lung cancer

3 Jul 2025

Abstract excerpt

Cancers rarely respond completely to immunotherapy. While tumors consist of multiple genetically distinct clones, whether this affects the potential for immune escape remains unclear due to an inability to isolate and propagate individual subclones from human cancers. Here, we leverage the multi-region TRACERx lung cancer evolution study to generate a patient-derived organoid - T cell co-culture platform that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Immune Cell Function and Interaction
Share to Immunotherapy and Immune Responses

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40614739
DOI: 10.1016/j.ccell.2025.06.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Subclonal immune evasion in non-small cell lung cancerPMID 40614739Read ↗

Tracking Genomic Cancer Evolution for Precision Medicine: The Lung TRACERx StudySemantic proximity Read ↗

Function-associated scRNA-seq on single lung cancer organoids unravels the immune landscape of tumor parenchymaSemantic proximity Read ↗

Genomic and immune heterogeneity of multiple synchronous lung adenocarcinoma at different developmental stages.Semantic proximity Read ↗

Genomic and immune heterogeneity of multiple synchronous lung adenocarcinoma at different developmental stagesSemantic proximity Read ↗

Common origin for effector and regulatory follicular and tissue-Adapted CD4+ T cells in Non-Small Cell Lung CancerSemantic proximity Read ↗

Geospatial immune variability illuminates differential evolution of lung adenocarcinoma.Semantic proximity Read ↗

Patient‐Derived Tumor Organoids Combined with Function‐Associated ScRNA‐Seq for Dissecting the Local Immune Response of Lung CancerSemantic proximity Read ↗

Genomic evolution of non-small cell lung cancer patient-derived xenograft modelsSemantic proximity Read ↗

Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA SequencingSemantic proximity Read ↗

Regional and clonal T cell dynamics at single cell resolution in immune checkpoint blockadeSemantic proximity Read ↗

Multimodal single-cell profiling of T cell specificity and reactivity in lung cancerSemantic proximity Read ↗

Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.