Molecular heterogeneity of non-small cell lung carcinoma patient-derived xenografts closely reflect their primary tumors.

doi:10.1002/ijc.30472

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Article

Molecular heterogeneity of non-small cell lung carcinoma patient-derived xenografts closely reflect their primary tumors.

International journal of cancer - 1 Feb 2017

Wang Dennis, Pham Nhu-An, Tong Jiefei, Sakashita Shingo, Allo Ghassan, Kim Lucia, Yanagawa Naoki, Raghavan Vibha, Wei Yuhong, To Christine, Trinh Quang M, Starmans Maud H W, Chan-Seng-Yue Michelle A, Chadwick Dianne, Li Lei, Zhu Chang-Qi, Liu Ni, Li Ming, Lee Sharon, Ignatchenko Vladimir, Strumpf Dan, Taylor Paul, Moghal Nadeem, Liu Geoffrey, Boutros Paul C, Kislinger Thomas, Pintilie Melania, Jurisica Igor, Shepherd Frances A, McPherson John D, Muthuswamy Lakshmi, Moran Michael F, Tsao Ming-Sound

Abstract excerpt

Availability of lung cancer models that closely mimic human tumors remains a significant gap in cancer research, as tumor cell lines and mouse models may not recapitulate the spectrum of lung cancer heterogeneity seen in patients. We aimed to establish a patient-derived tumor xenograft (PDX) resource from surgically resected non-small cell lung cancer (NSCLC). Fresh tumor tissue from surgical resection was...

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PMID: 27750381
DOI: 10.1002/ijc.30472

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