Article

A Genomically and Clinically Annotated Patient Derived Xenograft (PDX) Resource for Preclinical Research in Non-Small Cell Lung Cancer

2022-03-06

Abstract excerpt

Patient-derived xenograft models (PDXs) are an effective preclinical in vivo platform for testing the efficacy of novel drug and drug combinations for cancer therapeutics. Here we describe a repository of 79 genomically and clinically annotated lung cancer PDXs available from The Jackson Laboratory that have been extensively characterized for histopathological features, mutational profiles, gene expression, and c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c62ed1b8-78ba-54c1-883c-233810e51307
DOI: 10.1101/2022.03.06.483171

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Genomically and Clinically Annotated Patient Derived Xenograft (PDX) Resource for Preclinical Research in Non-Small Cell Lung CancerDOI 10.1101/2022.03.06.483171Read

Molecular heterogeneity of non-small cell lung carcinoma patient-derived xenografts closely reflect their primary tumors.Semantic proximity Read

Establishment of patient-derived non-small cell lung cancer xenograft models with genetic aberrations within EGFR, KRAS and FGFR1: useful tools for preclinical studies of targeted therapies.Semantic proximity Read

Utility of patient-derived xenografts to evaluate drug sensitivity and select optimal treatments for individual non-small-cell lung cancer patientsSemantic proximity Read

Genomic and transcriptomic analysis of a library of small cell lung cancer patient-derived xenograftsSemantic proximity Read

Human Lung Adenocarcinoma-Derived Organoid Models for Drug ScreeningSemantic proximity Read

Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer.Semantic proximity Read

Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived XenograftsSemantic proximity Read

Clinical Utility of Patient-Derived Xenografts to Determine Biomarkers of Prognosis and Map Resistance Pathways in EGFR-Mutant Lung Adenocarcinoma.Semantic proximity Read

Utility of patient-derived xenografts to evaluate drug sensitivity and select optimal treatments for individual non-small-cell lung cancer patients.Semantic proximity Read

Patient-derived xenograft models of human non-small cell lung cancer: pre-clinical and clinical factors for considerationSemantic proximity Read

A Lung Cancer Mouse Model DatabaseSemantic proximity Read

Organoid Cultures as Preclinical Models of Non-Small Cell Lung Cancer.Semantic proximity Read