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Article

Genetic Clonality as the Hallmark Driving Evolution of Non-Small Cell Lung Cancer

2 Apr 2022

Abstract excerpt

Data indicate that many driver alterations from the primary tumor of non-small cell lung cancer (NSCLC) are predominantly shared across all metastases; however, disseminating cells may also acquire a new genetic landscape across their journey. By comparing the constituent subclonal mutations between pairs of primary and metastatic samples, it is possible to derive the ancestral relationships between tumor clones,...

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PMID: 35406585
DOI: 10.3390/cancers14071813

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