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Article

Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts

26 Feb 2018

Abstract excerpt

Abstract Small cell lung cancer (SCLC) patient-derived xenografts (PDX) can be generated from biopsies or circulating tumor cells (CTC), though scarcity of tissue and low efficiency of tumor growth have previously limited these approaches. Applying an established clinical–translational pipeline for tissue collection and an automated microfluidic platform for CTC enrichment, we generated 17 biopsy-derived PDXs and...

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PMID: 29483136
DOI: 10.1158/2159-8290.cd-17-0935

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