Article
The evolution of lung cancer and impact of subclonal selection in TRACERx.
Nature - 1 Apr 2023
Frankell Alexander M, Dietzen Michelle, Al Bakir Maise, Lim Emilia L, Karasaki Takahiro, Ward Sophia, Veeriah Selvaraju, Colliver Emma, Huebner Ariana, Bunkum Abigail, Hill Mark S, Grigoriadis Kristiana, Moore David A, Black James R M, Liu Wing Kin, Thol Kerstin, Pich Oriol, Watkins Thomas B K, Naceur-Lombardelli Cristina, Cook Daniel E, Salgado Roberto, Wilson Gareth A, Bailey Chris, Angelova Mihaela, Bentham Robert, Martínez-Ruiz Carlos, Abbosh Christopher, Nicholson Andrew G, Le Quesne John, Biswas Dhruva, Rosenthal Rachel, Puttick Clare, Hessey Sonya, Lee Claudia, Prymas Paulina, Toncheva Antonia, Smith Jon, Xing Wei, Nicod Jerome, Price Gillian, Kerr Keith M, Naidu Babu, Middleton Gary, Blyth Kevin G, Fennell Dean A, Forster Martin D, Lee Siow Ming, Falzon Mary, Hewish Madeleine, Shackcloth Michael J, Lim Eric, Benafif Sarah, Russell Peter, Boleti Ekaterini, Krebs Matthew G, Lester Jason F, Papadatos-Pastos Dionysis, Ahmad Tanya, Thakrar Ricky M, Lawrence David, Navani Neal, Janes Sam M, Dive Caroline, Blackhall Fiona H, Summers Yvonne, Cave Judith, Marafioti Teresa, Herrero Javier, Quezada Sergio A, Peggs Karl S, Schwarz Roland F, Van Loo Peter, Miedema Daniël M, Birkbak Nicolai J, Hiley Crispin T, Hackshaw Allan, Zaccaria Simone, Jamal-Hanjani Mariam, McGranahan Nicholas, Swanton Charles
Abstract excerpt
Lung cancer is the leading cause of cancer-associated mortality worldwide1. Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer prospectively enrolled into the TRACERx study. This project aims to decipher lung cancer evolution and address the primary study endpoint: determining the relationship between intratumour heterogeneity...
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