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Article

The mutational landscape of STING-induced immunity.

Nature - 1 Jul 2026

Zhang Bing, Xu Pengbiao, Meng Yu, Gallay Laure, Lestelle François, Morel Hélène, Frémond Marie-Louise, Correia Bruno E, Ablasser Andrea

Abstract excerpt

Stimulator of interferon genes (STING) is an evolutionary conserved immune signalling protein with key roles in host defence, cancer, senescence and inflammation1-3. Downstream of STING, type I interferon, inflammatory cytokine signalling and non-canonical autophagy are governed by a multilayered mechanism integrating ligand-induced structural transitions, protein-protein interactions and coordinated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42343134
DOI: 10.1038/s41586-026-10685-3
PMCID: PMC13421317

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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