Article

SEMplMe: A tool for integrating DNA methylation effects in transcription factor binding affinity predictions

2020-08-14

Abstract excerpt

<h4>Motivation</h4> Aberrant DNA methylation in transcription factor binding sites has been shown to lead to anomalous gene regulation that is strongly associated with human disease. However, the majority of methylation-sensitive positions within transcription factor binding sites remain unknown. Here we introduce SEMplMe, a computational tool to generate predictions of the effect of methylation on transcription...

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Literature Corpus work: 62a1987c-23a3-5911-a227-1e1d0c31dce6
DOI: 10.1101/2020.08.13.250118

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