Article

Diosmetin blocks type Ⅰ interferon signaling by metabolic control of phosphatidylethanolamine

2023-02-09

Abstract excerpt

<title>Abstract</title> <p>Type I interferon (IFN-I) is essential in the development of Systemic Lupus Erythematosus (SLE) and many other autoimmune diseases. To explore the metabolic regulations of IFN-I signaling pathway, we conducted a high through-put screening of a small molecule library and identified diosmetin as a potent compound for blocking IFN-I signaling. We showed diosmetin functioned by preventing t...

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Literature Corpus work: 3b61570f-ced1-56cd-8d96-181eaa2ae021
DOI: 10.21203/rs.3.rs-2528258/v1

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Diosmetin blocks type Ⅰ interferon signaling by metabolic control of phosphatidylethanolamineDOI 10.21203/rs.3.rs-2528258/v1Read

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