Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome

Abstract excerpt

Hyperactive interferon (IFN) signaling is a hallmark of Down syndrome (DS), a condition caused by trisomy 21 (T21); strategies that normalize IFN signaling could benefit this population. Mediator-associated kinases CDK8 and CDK19 drive inflammatory responses through incompletely understood mechanisms. Using sibling-matched cell lines with/without T21, we investigated Mediator kinase function in the context of hype...

Topics

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• Disease Models, Animal
• Down Syndrome
• Down syndrome and intellectual disability research
• Heart Defects, Congenital
• Interferons
• Mice
• Phenotype
• Receptors, Interferon

Identifiers and source

Literature Corpus work

02963b9f-dded-5546-a23f-537ab795c9b7

DOI

10.1101/2023.07.05.547813