Article

WY14643 Increases Herpesvirus Replication Independently of PPARα Expression and Inhibits IFNβ Production

2021-11-02

Abstract excerpt

Peroxisome proliferator activated receptor (PPAR) agonists are commonly used to treat metabolic disorders in humans because they regulate fatty acid oxidation and cholesterol metabolism. In addition to their roles in controlling metabolism, PPAR agonists also regulate inflammation and are immunosuppressive in models of autoimmunity. We aimed to test whether activation of PPARα with clinically relevant ligands coul...

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Literature Corpus work: 0680a006-8a2b-59bc-a224-1128d67c811d
DOI: 10.1101/2021.10.29.466551

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