Article

Isolevuglandins promote autoimmunity and hypertension in systemic lupus erythematosus

2020-02-12

Abstract excerpt

<h4>ABSTRACT</h4> Hypertension, vascular inflammation and renal inflammation are characteristic of systemic lupus erythematosus (SLE), a multisystem autoimmune disease that is complex and poorly understood. Oxidation products of arachidonic and other fatty acids, termed isolevuglandins (isoLG) lead to formation of post-translational protein modifications that are immunogenic. We demonstrate isoLG enrichment in den...

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Literature Corpus work: 2754a1d3-4593-5461-bc13-2e4094bf008a
DOI: 10.1101/2020.02.10.20021741

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