Article

Reducing Glucocorticoid Burden in Lupus with Omega-3 Fatty Acids: Docosahexaenoic Acid Augments Prednisone Efficacy in Maintaining Cyclophosphamide-Induced Remission of Preclinical Lupus Nephritis

2026-01-08

Abstract excerpt

<h4>Background</h4> Managing lupus nephritis (LN) remains challenging due to relapses after immunosuppressive induction and toxicity from long-term glucocorticoid (GC) maintenance therapy. Dietary omega-3 fatty acids prevent LN onset in preclinical models, but their role in maintaining remission post-induction remains unstudied. <h4>Methods</h4> The silica-accelerated LN (SALN) model using lupus-prone NZBWF1 mic...

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Literature Corpus work: df1a3541-327c-573e-a6ea-2749b35bb46a
DOI: 10.64898/2026.01.07.698195

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