Article

Genome-Wide CRISPR/Cas9 Screening Reveals Lipid Metabolism and Inflammatory Signalling as Modulators of Ganoderic Acid DM Cytotoxicity

2025-10-15

Abstract excerpt

Ganoderic Acid DM (GA-DM), a triterpenoid derived from Ganoderma lucidum , exhibits anti-cancer and anti-diabetic activities, but the underlying mechanisms of action remain unclear. To identify genetic modulators of GA-DM response, we conducted a genome-wide CRISPR/Cas9 knockout screen in human melanoma cells. The screen revealed key roles for genes regulating lipid metabolism and inflammatory signalling, particu...

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Literature Corpus work: 6b4f10d9-77bf-5819-91a3-2cd5c1cd903d
DOI: 10.1101/2025.10.14.682027

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Genome-Wide CRISPR/Cas9 Screening Reveals Lipid Metabolism and Inflammatory Signalling as Modulators of Ganoderic Acid DM CytotoxicityDOI 10.1101/2025.10.14.682027Read

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