Article

<i>APOE</i> ε4 defines a systemic immune endophenotype independent of clinical trajectory in amyotrophic lateral sclerosis

2026-02-04

Abstract excerpt

<h4>Background</h4> Amyotrophic lateral sclerosis (ALS) is clinically heterogeneous, and genetic modifiers may drive molecular endophenotypes without obvious clinical stratification. The apolipoprotein E ε4 ( APOE ε4) allele is a major Alzheimer’s disease risk allele, but its biological impact in ALS remains unclear. <h4>Methods</h4> Using the Answer ALS cohort, longitudinal motor, cognitive, and neuropsychiat...

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Literature Corpus work: 3b5b465d-970a-55fe-b405-f76d6ebe0b04
DOI: 10.64898/2026.02.02.703399

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