Article

Absorption and Co-expression Modules Show Where Polygenic and Proteomic Risk Scores Diverge in Neurodegenerative Diseases

2026-08-27

Abstract excerpt

Polygenic and proteomic risk scores are both proposed for pre-symptomatic stratification, yet the extent to which they provide overlapping or complementary information has not been measured across neurodegenerative disease. To quantify this overlap, we define absorption as the fraction of a polygenic score's predictive contribution accounted for by an out-of-fold proteomic score and estimate it among 9,434 to 9,82...

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Literature Corpus work: 32fb7d49-793c-58f7-afea-1183dbc14dee
DOI: 10.64898/2026.08.24.26361271

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