Article

Prioritization of therapeutic targets for amyotrophic lateral sclerosis using protein-wide Mendelian randomization analysis

2023-11-23

Abstract excerpt

<h4>Background and Objectives</h4> Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease with an increasing global burden. Available treatments for ALS present marginal efficacy. To identify novel candidate therapeutic targets for ALS, we conducted a proteome-wide Mendelian randomization (MR) study. <h4>Methods</h4> We leveraged data from the largest summary statistics for ALS to...

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Literature Corpus work: db5d0e71-0a29-5723-a099-a6c4495ba1d3
DOI: 10.1101/2023.11.22.23298887

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