Article

Redefining ALS: Large-scale proteomic profiling reveals a prolonged pre-diagnostic phase with immune, muscular, metabolic, and brain involvement

2025-09-01

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with a largely unknown duration and pathophysiology of the pre-diagnostic phase, especially for the common non-monogenic form. <bold>Methods:</bold> We leveraged the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort with up to 30 years of follow-up to identify inci...

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Literature Corpus work: 525a7d91-56b0-5a5b-8ae2-b579d12a5afe
DOI: 10.21203/rs.3.rs-7452736/v1

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