Article

Redefining ALS: Large-scale proteomic profiling reveals a prolonged pre-diagnostic phase with immune, muscular, metabolic, and brain involvement

2025-08-28

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with a largely unknown duration and pathophysiology of the pre-diagnostic phase, especially for the common non-monogenic form. <h4>Methods</h4> We leveraged the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort with up to 30 years of follow-up to identify incident ALS cases ac...

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Literature Corpus work: 0205dd76-aa96-5b0a-be82-d268e30c4de2
DOI: 10.1101/2025.08.20.25334061

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