Article

The proto-oncogene c-Src phosphorylates cGAS to reduce DNA binding and activation

2022-10-07

Abstract excerpt

<h4>Summary</h4> cGMP-AMP synthase (cGAS) is a DNA sensor and responsible for inducing an anti-tumor immune response. Recent studies reveal cGAS is frequently inhibited in cancer, and therapeutic targets to promote anti-tumor cGAS function remain elusive. c-Src is a proto-oncogene tyrosine kinase and is expressed at elevated levels in numerous cancers. Here, we demonstrate that c-Src expression in tumors from var...

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Literature Corpus work: 3b4c1288-336c-5168-910b-509a155abc09
DOI: 10.1101/2022.10.07.511364

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