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Article

DNA-PK interacts with cyclic dinucleotides and inhibits type I Interferon responses

2024-09-20

Abstract excerpt

<h4>Summary</h4> Inflammatory signal termination is critical for the maintenance of homeostasis. Cyclic dinucleotides (CDN) are second messengers that trigger inflammatory responses through the activation of the Stimulator of Interferon Genes (STING) signaling platform. No broad-acting direct regulator of intracellular CDNs has been identified in mammals to date. We show that the DNA-dependent protein kinase cata...

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Identifiers and source

Literature Corpus work
267238d2-abde-565e-95db-8b3b3c6c318e
DOI
10.1101/2024.09.17.613246
Open publication

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DNA-PK interacts with cyclic dinucleotides and inhibits type I Interferon responsesDOI 10.1101/2024.09.17.613246
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