Article

An active chromatin interactome in relevant cell lines elucidates biological mechanisms at genetic risk loci for dermatological traits

2020-03-06

Abstract excerpt

Chromatin looping between regulatory elements and gene promoters presents a potential mechanism whereby disease risk variants affect their target genes. Here we use H3K27ac HiChIP, a method for assaying the active chromatin interactome in two cell lines: keratinocytes and skin derived CD8+ T cells. We integrate public datasets for a lymphoblastoid cell line and primary CD4+ T cells and identify gene targets at ris...

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Literature Corpus work: 3b43d243-3b72-5148-a992-eb12a5bf3ed6
DOI: 10.1101/2020.03.05.973271

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