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Chromatin-based techniques map DNA interaction landscapes in psoriasis susceptibility loci and highlight <i>KLF4</i> as a target gene in 9q31

2019-10-30

Abstract excerpt

Genome-wide association studies (GWAS) have uncovered many genetic risk loci for psoriasis, yet many remain uncharacterised in terms of the causal gene and their biological mechanism in disease. Here, we use a disease-focused Capture Hi-C experiment to link psoriasis-associated variants with their target genes in psoriasis-relevant cell lines (HaCaT keratinocytes and My-La CD8+ T cells). We confirm previously assi...

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Literature Corpus work
b14221d2-4655-5ccc-ba84-be4dec6d0cab
DOI
10.1101/822304
Open publication

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Chromatin-based techniques map DNA interaction landscapes in psoriasis susceptibility loci and highlight <i>KLF4</i> as a target gene in 9q31DOI 10.1101/822304
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