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Article

Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31.

BMC biology - 4 May 2020

Ray-Jones Helen, Duffus Kate, McGovern Amanda, Martin Paul, Shi Chenfu, Hankinson Jenny, Gough Oliver, Yarwood Annie, Morris Andrew P, Adamson Antony, Taylor Christopher, Ding James, Gaddi Vasanthi Priyadarshini, Fu Yao, Gaffney Patrick, Orozco Gisela, Warren Richard B, Eyre Steve

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have uncovered many genetic risk loci for psoriasis, yet many remain uncharacterised in terms of the causal gene and their biological mechanism in disease. This is largely a result of the findings that over 90% of GWAS variants map outside of protein-coding DNA and instead are enriched in cell type- and stimulation-specific gene regulatory regions. RESULTS: Here,...

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Identifiers

PMID: 32366252
DOI: 10.1186/s12915-020-00779-3
PMCID: PMC7199343

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