Article
Chromatin interactions in differentiating keratinocytes reveal novel atopic dermatitis- and psoriasis-associated genes.
The Journal of allergy and clinical immunology - 1 May 2021
Sahlén Pelin, Spalinskas Rapolas, Asad Samina, Mahapatra Kunal Das, Höjer Pontus, Anil Anandashankar, Eisfeldt Jesper, Srivastava Ankit, Nikamo Pernilla, Mukherjee Anaya, Kim Kyu-Han, Bergman Otto, Ståhle Mona, Sonkoly Enikö, Pivarcsi Andor, Wahlgren Carl-Fredrik, Nordenskjöld Magnus, Taylan Fulya, Bradley Maria, Tapia-Páez Isabel
Abstract excerpt
BACKGROUND: Hundreds of variants associated with atopic dermatitis (AD) and psoriasis, 2 common inflammatory skin disorders, have previously been discovered through genome-wide association studies (GWASs). The majority of these variants are in noncoding regions, and their target genes remain largely unclear. OBJECTIVE: We sought to understand the effects of these noncoding variants on the development of AD and...
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