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Article

Chromatin Looping Links Target Genes with Genetic Risk Loci for Dermatological Traits.

The Journal of investigative dermatology - 1 Aug 2021

Shi Chenfu, Ray-Jones Helen, Ding James, Duffus Kate, Fu Yao, Gaddi Vasanthi Priyadarshini, Gough Oliver, Hankinson Jenny, Martin Paul, McGovern Amanda, Yarwood Annie, Gaffney Patrick, Eyre Steve, Rattray Magnus, Warren Richard B, Orozco Gisela

Abstract excerpt

Chromatin looping between regulatory elements and gene promoters presents a potential mechanism whereby disease risk variants affect their target genes. In this study, we use H3K27ac HiChIP, a method for assaying the active chromatin interactome in two cell lines: keratinocytes and skin lymphoma-derived CD8+ T cells. We integrate public datasets for a lymphoblastoid cell line and primary CD4+ T cells and identify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Enhancer Elements, Genetic

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Source

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Identifiers

PMID: 33607115
DOI: 10.1016/j.jid.2021.01.015
PMCID: PMC8315765

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