Article
Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants.
Nature communications - 24 May 2017
Tsoi Lam C, Stuart Philip E, Tian Chao, Gudjonsson Johann E, Das Sayantan, Zawistowski Matthew, Ellinghaus Eva, Barker Jonathan N, Chandran Vinod, Dand Nick, Duffin Kristina Callis, Enerbäck Charlotta, Esko Tõnu, Franke Andre, Gladman Dafna D, Hoffmann Per, Kingo Külli, Kõks Sulev, Krueger Gerald G, Lim Henry W, Metspalu Andres, Mrowietz Ulrich, Mucha Sören, Rahman Proton, Reis Andre, Tejasvi Trilokraj, Trembath Richard, Voorhees John J, Weidinger Stephan, Weichenthal Michael, Wen Xiaoquan, Eriksson Nicholas, Kang Hyun M, Hinds David A, Nair Rajan P, Abecasis Gonçalo R, Elder James T
Abstract excerpt
Psoriasis is a complex disease of skin with a prevalence of about 2%. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for psoriasis to date, including data from eight different Caucasian cohorts, with a combined effective sample size >39,000 individuals. We identified 16 additional psoriasis susceptibility loci achieving genome-wide significance, increasing the number of...
Topics
- Age of Onset
- Gene Regulatory Networks
- Genetic Loci
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Interferons