Article
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
Nature genetics - 1 Dec 2012
Tsoi Lam C, Spain Sarah L, Knight Jo, Ellinghaus Eva, Stuart Philip E, Capon Francesca, Ding Jun, Li Yanming, Tejasvi Trilokraj, Gudjonsson Johann E, Kang Hyun M, Allen Michael H, McManus Ross, Novelli Giuseppe, Samuelsson Lena, Schalkwijk Joost, Ståhle Mona, Burden A David, Smith Catherine H, Cork Michael J, Estivill Xavier, Bowcock Anne M, Krueger Gerald G, Weger Wolfgang, Worthington Jane, Tazi-Ahnini Rachid, Nestle Frank O, Hayday Adrian, Hoffmann Per, Winkelmann Juliane, Wijmenga Cisca, Langford Cordelia, Edkins Sarah, Andrews Robert, Blackburn Hannah, Strange Amy, Band Gavin, Pearson Richard D, Vukcevic Damjan, Spencer Chris C A, Deloukas Panos, Mrowietz Ulrich, Schreiber Stefan, Weidinger Stephan, Koks Sulev, Kingo Külli, Esko Tonu, Metspalu Andres, Lim Henry W, Voorhees John J, Weichenthal Michael, Wichmann H Erich, Chandran Vinod, Rosen Cheryl F, Rahman Proton, Gladman Dafna D, Griffiths Christopher E M, Reis Andre, Kere Juha, Nair Rajan P, Franke Andre, Barker Jonathan N W N, Abecasis Goncalo R, Elder James T, Trembath Richard C
Abstract excerpt
To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped on the Immunochip, including 10,588 cases and 22,806 controls. We identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals. We also identified, using conditional analyses, five...
Topics
- CARD Signaling Adaptor Proteins
- Core Binding Factor Alpha 3 Subunit
- DEAD Box Protein 58