Back to search

Article

Genetic dissection of hippocampal sclerosis of ageing using magnetic resonance imaging surrogates

2025-05-13

Abstract excerpt

<title>Abstract</title> <p><bold>BACKROUND</bold>: Hippocampal sclerosis of aging (HS-aging) is frequently present in individuals over 85 who die with dementia. Recent studies suggest that some loci associated with Alzheimer’s disease (AD) may be more related to HS-aging. We aimed to find AD-associated SNPs potentially related to HS-aging. <bold>METHODS</bold>: We used different regression models to assess the re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
3aa8d00e-e452-5e7c-8c3b-ebfa04da730a
DOI
10.21203/rs.3.rs-6429978/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Genetic dissection of hippocampal sclerosis of ageing using magnetic resonance imaging surrogatesDOI 10.21203/rs.3.rs-6429978/v1
Genetic dissection of hippocampal sclerosis of ageing using magnetic resonance imaging surrogatesSemantic proximity
Identification of novel associations of candidate loci with Alzheimer’s disease by leveraging the shared genetic basis with hippocampal volumeSemantic proximity
APOE, Immune Factors, Sex, and Diet Interact to Shape Brain Networks in Mouse Models of AgingSemantic proximity
<i>APOE</i> ɛ2 vs <i>APOE</i> ɛ4 dosage shows sex-specific links to hippocampus-default network subregion co-variationSemantic proximity
Hippocampal Sclerosis of Aging, a Common Alzheimer's Disease 'Mimic': Risk Genotypes are Associated with Brain Atrophy Outside the Temporal Lobe.Semantic proximity
Associations between Alzheimer’s disease polygenic risk scores and hippocampal subfield volumes in 17,161 UK Biobank participantsSemantic proximity
Associations between Alzheimer’s disease polygenic risk scores and hippocampal subfield volumes in 17,161 UK Biobank participantsSemantic proximity
Age-related polygenic effects of Alzheimer's disease on brain structures and cognition in middle aged and elderly adults from UK BiobankSemantic proximity
Polygenic risk for Alzheimer's disease in healthy aging: age-related and APOE-driven effects on brain structures and cognition.Semantic proximity
Cognitively Healthy Centenarians are genetically protected against Alzheimer’s disease specifically in immune and endo-lysosomal systemsSemantic proximity
Leveraging selective hippocampal vulnerability among Alzheimer’s disease subtypes reveals a novel tau binding partner SERPINA5Semantic proximity
APOE alleles are associated with sex-specific structural differences in brain regions affected in Alzheimer's disease and related dementia.Semantic proximity
Select a neighboring publication to make it the new centre.