Article

Quantification and discovery of sequence determinants of protein per mRNA amount in 29 human tissues

2018-06-27

Abstract excerpt

Despite their importance in determining protein abundance, a comprehensive catalogue of sequence features controlling protein-to-mRNA (PTR) ratios and a quantification of their effects is still lacking. Here we quantified PTR ratios for 11,575 proteins across 29 human tissues using matched transcriptomes and proteomes. We analyzed the contribution of known sequence determinants of protein synthesis and degradation...

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Identifiers and source

Literature Corpus work: f9f2b198-dc76-50aa-8f03-8817a778c70a
DOI: 10.1101/353763

Open publication

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