Article

Quantitative fate mapping: Reconstructing progenitor field dynamics via retrospective lineage barcoding

2022-02-14

Abstract excerpt

Natural and induced somatic mutations that accumulate in the genome during development record the phylogenetic relationships of cells; however, whether these lineage barcodes can capture the dynamics of complex progenitor fields remains unclear. Here, we introduce quantitative fate mapping, an approach to simultaneously map the fate and quantify the commitment time, commitment bias, and population size of multiple...

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Literature Corpus work: 47e80c86-208c-50ad-b1fb-83bbb0be59dd
DOI: 10.1101/2022.02.13.480215

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