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Transgenic dCas9-DNMT3A mouse lines enable <i>ex vivo</i> and <i>in vivo</i> methylation editing with locus-dependent transcriptional effects

2026-02-27

Abstract excerpt

The number of epigenome-wide association studies linking CpG DNA methylation with disease, traits and exposures, continues to rise. Despite the rapid development of epigenome editing tools, establishing causation remains challenging, particularly in vivo . In this study, we developed and characterized three Cre-dependent CRISPR-based mouse lines that enable locus-specific DNA methylation deposition by either cons...

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Literature Corpus work
3a9e676b-d622-58b2-8d55-cb486085f039
DOI
10.64898/2026.02.26.708277
Open publication

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Transgenic dCas9-DNMT3A mouse lines enable <i>ex vivo</i> and <i>in vivo</i> methylation editing with locus-dependent transcriptional effectsDOI 10.64898/2026.02.26.708277
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