Article

Modulating immune cell fate and inflammation through CRISPR-mediated DNA methylation editing

2024-07-10

Abstract excerpt

<h4>ABSTRACT</h4> DNA methylation is traditionally associated with gene silencing, but its causal relationship and role in shaping cell fate decisions still need to be fully elucidated. Here, we conducted a genome-wide analysis to investigate the relationship between DNA methylation and gene expression at gene regulatory regions in human immune cells. By utilizing CRISPR-dCas9 DNA methylation editing tools, we s...

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Literature Corpus work: d7706170-b9a3-5dc8-86d0-da63f061c6bf
DOI: 10.1101/2024.07.10.599183

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