Article

<i>In-utero</i> rescue of neurological dysfunction in a mouse model of Wiedemann-Steiner syndrome

2024-07-23

Abstract excerpt

Wiedemann-Steiner syndrome (WDSTS) is a rare genetic cause of intellectual disability primarily caused by heterozygous loss of function variants in the gene encoding the histone methyltransferase KMT2A. Prior studies have shown successful postnatal amelioration of disease phenotypes for Rett, Rubinstein-Taybi and Kabuki syndromes, related Mendelian disorders of the epigenetic machinery. To explore whether the neur...

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Literature Corpus work: 81e5b9e0-5b0a-54e8-b09c-673773776d6c
DOI: 10.1101/2024.07.19.604339

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