Article
Epigenome editing reveals core DNA methylation for imprinting control in the Dlk1-Dio3 imprinted domain.
Nucleic acids research - 20 May 2022
Kojima Shin, Shiochi Naoya, Sato Kazuki, Yamaura Mamiko, Ito Toshiaki, Yamamura Nodoka, Goto Naoki, Odamoto Mika, Kobayashi Shin, Kimura Tohru, Sekita Yoichi
Abstract excerpt
The Dlk1-Dio3 imprinted domain is controlled by an imprinting control region (ICR) called IG-DMR that is hypomethylated on the maternal allele and hypermethylated on the paternal allele. Although several genetic mutation experiments have shown that IG-DMR is essential for imprinting control of the domain, how DNA methylation itself functions has not been elucidated. Here, we performed both gain and loss of DNA...
Topics
- Alleles
- Animals
- Calcium-Binding Proteins
- DNA Methylation
- Epigenome
- Genomic Imprinting
- Mice
- RNA, Long Noncoding