Article

<i>Dnmt3a</i> mutations limit normal and autoreactive Tfh differentiation

2024-02-21

Abstract excerpt

Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation, strongly associated with the activity of autoreactive CD4+ T cells. DNMT3A mutations are the most common somatic mutations found in the hematopoietic system of patients with rheumatoid arthritis. However, the role of DNMT3A in CD4+ T cells and CD4+ T follicular helper (Tfh) cells is poorly understood. Since somatic mutations a...

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Literature Corpus work: b3a9ff9b-7cf7-5cc4-81d8-5f75067519f4
DOI: 10.1101/2024.02.16.580463

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