Article

Locus-Specific DNA Methylation Editing in Mammalian Cells using a CRISPR-Based System

2021-10-12

Abstract excerpt

DNA methylation is a key epigenetic modification implicated in the pathogenesis of numerous human diseases, including cancer development and metastasis. Gene promoter methylation changes are widely associated with transcriptional deregulation and disease progression. The advent of CRISPR-based technologies has provided a powerful toolkit for locus-specific manipulation of the epigenome. Here, we describe a compreh...

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Literature Corpus work: 1f0e6698-d105-539b-b415-7656806ab8f4
DOI: 10.1101/2021.10.12.463855

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