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Article

Regulation of<i>Aicda</i>expression and AID activity

27 Nov 2012

Abstract excerpt

Activation-induced cytidine deaminase (AID) is expressed in a B cell differentiation stage-specific fashion and is essential for immunoglobulin (Ig) gene class switch DNA recombination (CSR) and somatic hypermutation (SHM). CSR and SHM play a central role in the maturation of antibody and autoantibody responses. AID displays a mutagenic activity by catalyzing targeted deamination of deoxycytidine (dC) residues in...

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PMID: 23181381
DOI: 10.3109/08916934.2012.749244

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