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Article

Characterization of the immunoglobulin lambda chain locus from diverse populations reveals extensive genetic variation.

Genes and immunity - 1 Feb 2023

Gibson William S, Rodriguez Oscar L, Shields Kaitlyn, Silver Catherine A, Dorgham Abdullah, Emery Matthew, Deikus Gintaras, Sebra Robert, Eichler Evan E, Bashir Ali, Smith Melissa L, Watson Corey T

Abstract excerpt

Immunoglobulins (IGs), crucial components of the adaptive immune system, are encoded by three genomic loci. However, the complexity of the IG loci severely limits the effective use of short read sequencing, limiting our knowledge of population diversity in these loci. We leveraged existing long read whole-genome sequencing (WGS) data, fosmid technology, and IG targeted single-molecule, real-time (SMRT) long-read...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36539592
DOI: 10.1038/s41435-022-00188-2
PMCID: PMC10041605

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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