Article

MCART1 is required for mitochondrial NAD transport

2020-08-28

Abstract excerpt

The nicotinamide adenine dinucleotide (NAD+/NADH) pair is a cofactor in redox reactions and is particularly critical in mitochondria as it connects substrate oxidation by the tricarboxylic acid (TCA) cycle to ATP generation by the electron transport chain (ETC) and oxidative phosphorylation. While a mitochondrial NAD + transporter has been identified in yeast, how NAD enters mitochondria in higher eukaryotes is u...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3a8c48ab-09b1-596f-8da0-73e25968f3bb
DOI: 10.1101/2020.08.28.267252

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MCART1 is required for mitochondrial NAD transportDOI 10.1101/2020.08.28.267252Read

A systematic genetic interaction map of human solute carriers assigns a role to SLC25A51/MCART1 in mitochondrial NAD uptakeSemantic proximity Read

Mitochondrial dysfunctions in cancer: genetic defects and oncogenic signaling impinging on TCA cycle activity.Semantic proximity Read

Roles of MT-ND1 in Cancer.Semantic proximity Read

Regulation of Cancer and Cancer-Related Genes via NAD +Semantic proximity Read

Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion.Semantic proximity Read

Nuclear NAD <sup>+</sup> -biosynthetic enzyme NMNAT1 facilitates survival of developing retinal neuronsSemantic proximity Read

Mitochondrial NAD+ gradient sustained by membrane potential and transport.Semantic proximity Read

Dynamics of Mitochondrial NAD <sup>+</sup> Import Reveal Preference for Oxidized Ligand and Substrate Led TransportSemantic proximity Read

Aconitase couples metabolic regulation to mitochondrial DNA maintenance.Semantic proximity Read

The balance between NAD+ biosynthesis and consumption in ageingSemantic proximity Read

Therapeutic potential of boosting NAD+ in aging and age-related diseasesSemantic proximity Read

Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death.Semantic proximity Read