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The balance between NAD+ biosynthesis and consumption in ageing

9 Sept 2021

Abstract excerpt

Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme in redox reactions. NAD+ is also important in cellular signalling as it is consumed by PARPs, SARM1, sirtuins and CD38. Cellular NAD+ levels regulate several essential processes including DNA repair, immune cell function, senescence, and chromatin remodelling. Maintenance of these cellular processes is important for healthy ageing and lifespan....

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PMID: 34509469
DOI: 10.1016/j.mad.2021.111569

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