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Article

Regulation of Cancer and Cancer-Related Genes via NAD +

16 Jan 2018

Abstract excerpt

Significance: NAD+ is an essential redox cofactor in cellular metabolism and has emerged as an important regulator of a wide spectrum of disease conditions, most notably, cancers. As such, various strategies targeting NAD+ synthesis in cancers are in clinical trials. Recent Advances: Being a substrate required for the activity of various enzyme families, especially sirtuins and poly(adenosine diphosphate...

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Identifiers

PMID: 29334761
DOI: 10.1089/ars.2017.7478

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