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Article

Mitochondrial NAD+ gradient sustained by membrane potential and transport.

Science advances - 21 Nov 2025

Goyal Shivansh, Lyons Scott N, Cambronne Xiaolu A

Abstract excerpt

SLC25A51 is required for the replenishment of free nicotinamide adenine dinucleotide (oxidized form) (NAD+) into mammalian mitochondria. However, it is not known how SLC25A51 imports this anionic molecule to sustain elevated NAD+ concentrations in the matrix. Understanding this would reveal regulatory mechanisms used to maintain critical bioenergetic gradients for cellular respiration, oxidative mitochondrial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41270176
DOI: 10.1126/sciadv.aea7460
PMCID: PMC12637306

Genes

SLC25A51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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