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Article

Mitochondrial dysfunctions in cancer: genetic defects and oncogenic signaling impinging on TCA cycle activity.

Cancer letters - 28 Jan 2015

Desideri Enrico, Vegliante Rolando, Ciriolo Maria Rosa

Abstract excerpt

The tricarboxylic acid (TCA) cycle is a central route for oxidative metabolism. Besides being responsible for the production of NADH and FADH2, which fuel the mitochondrial electron transport chain to generate ATP, the TCA cycle is also a robust source of metabolic intermediates required for anabolic reactions. This is particularly important for highly proliferating cells, like tumour cells, which require a...

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PMID: 24614286
DOI: 10.1016/j.canlet.2014.02.023

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