Article

A systematic genetic interaction map of human solute carriers assigns a role to SLC25A51/MCART1 in mitochondrial NAD uptake

2020-09-01

Abstract excerpt

Solute Carriers (SLCs) represent the largest family of human transporter proteins, consisting of more than 400 members 1,2 . Despite the importance of these proteins in determining metabolic states and adaptation to environmental changes, a large proportion of them is still orphan and lacks associated substrates 1,3,4 . Here we describe a systematic mapping of genetic interactions among SLCs in human cells. Netw...

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Literature Corpus work: dbf483b4-ed59-555d-96fa-37140879c116
DOI: 10.1101/2020.08.31.275818

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