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Article

Aconitase couples metabolic regulation to mitochondrial DNA maintenance.

Science (New York, N.Y.) - 4 Feb 2005

Chen Xin Jie, Wang Xiaowen, Kaufman Brett A, Butow Ronald A

Abstract excerpt

Mitochondrial DNA (mtDNA) is essential for cells to maintain respiratory competency and is inherited as a protein-DNA complex called the nucleoid. We have identified 22 mtDNA-associated proteins in yeast, among which is mitochondrial aconitase (Aco1p). We show that this Krebs-cycle enzyme is essential for mtDNA maintenance independent of its catalytic activity. Regulation of ACO1 expression by the HAP and...

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Identifiers

PMID: 15692048
DOI: 10.1126/science.1106391

Genes

ACO1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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