Article

Dynamics of Mitochondrial NAD <sup>+</sup> Import Reveal Preference for Oxidized Ligand and Substrate Led Transport

2022-11-06

Abstract excerpt

SLC25A51 is a member of the mitochondrial carrier family (MCF) but lacks key residues that have been attributed to the mechanism of other nucleotide MCF transporters. Thus, how SLC25A51 transports NAD + across the inner mitochondrial membrane remains unclear. To elucidate its mechanism, we used Molecular Dynamic simulations to study reconstituted SLC25A51 homology models in lipid bilayers. We observed spontaneous...

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Literature Corpus work: 4433effd-bbbc-5a43-99b9-cff69b46f50e
DOI: 10.1101/2022.11.04.515224

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